From an article in the Globe and Mail:
An international research team has overturned the harmonious message that flowed from the Human Genome Project in 2000 and discovered more DNA differences exist among people than the experts expected.
Using new technology to study the genomes of 270 volunteers from four corners of the world, researchers have found that while people do indeed inherit one chromosome from each parent, they do not necessarily inherit one gene from mom and another from dad.
One parent can pass down to a child three or more copies of a single gene. In some cases, people can inherit as many as eight or 10 copies. In rare instances a person might be missing a gene.
Yet despite these anomalies, they still appear to be healthy — countering the notion of what doctors have deemed “normal” in genetics.
The work highlights how DNA helps to make each human unique, hinting that a towering basketball player, for example, might boast extra copies of a growth gene…
Said Steve Scherer, a senior scientist at the Hospital for Sick Children in Toronto and study co-author:
“The genome is like an accordion that can stretch or shrink . . . so you have no idea what’s normal.”
The Sick Kids team worked on the project for more than two years with scientists at Harvard Medical School, the Wellcome Trust Sanger Institute in England, the University of Tokyo and the California-based Affymetrix Corp.
Their research finds that the size of at least 12 per cent of the genome — including 2,900 genes and regions between them — can differ dramatically between people, and in some cases, between certain ethnic groups.
The size differences are the result of DNA that is either duplicated or deleted or contains unexpected added bits of genetic code. Scientists call the phenomenon “copy number variation” or CNV for short. And it is already reshaping genetic research.
Robert Hegele, a noted genetic scientist at the Robarts Research Institute in London, Ont., who read the study, says:
“When we’re accounting for what the human genome means, there’s not going to be a single human genome map that is going to be useful to one person. It’s a huge surprise that there’s so much variation of this type . . . that is so common in so many healthy people.”
Sorry to be so unoriginal, but life has been busy and I don’t have time to do the proper research and write things up.